Synthetic Route of 117103-53-4,Some common heterocyclic compound, 117103-53-4, name is 2-Bromo-5-nitropyrazine, molecular formula is C4H2BrN3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 40 2 (R)- (3-CHLORO-4-METHANESULFONYL-PHENYL)-3-CYCLOPENTYL-N- [5- (2-HYDROXY-L- hydroxymethyl-ethyl)-pyrazin-2-yl]-propionamide [000237] A solution of 2-BROMO-5-NITROPYRAZINE (3.0 g, 14.7 mmol) in tetrahydrofuran (24.5 mL) was treated with DIETHYLMALONATE (3.35 mL, 22.0 mmol) and potassium carbonate (5.08g, 36.7 MMOL). The mixture was then stirred at 90-95C overnight. At this time, the reaction was cooled to 25C and then poured onto a 1N aqueous hydrochloric acid solution (60 mL). This solution was diluted with a saturated aqueous sodium chloride solution (50 mL) and then was extracted with ethyl acetate (3 x 75 mL). The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo. Biotage chromatography (FLASH 40M, Silica 25% ethyl acetate/hexanes) afforded 2- (5-NITRO-PYRAZIN-2-YL)-MALONIC acid diethyl ester (3.28 g, 78%) as a pale yellow oil: EI-HRMS M/E calcd for CILHL3N306 (M) 283. 0804, found 283.0801.
The synthetic route of 117103-53-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2004/52869; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem