Synthetic Route of 25710-18-3, A common heterocyclic compound, 25710-18-3, name is 2,3-Dichloropyrido[2,3-b]pyrazine, molecular formula is C7H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of 2,3-dichloropyrazine or its derivatives (1, 1.0 equiv), substituted phenols (2a-p) (1.0 equiv) and anhydrous AlCl3 (1.0 equiv) in dichloroethane (5 mL) was stirred at 80 oC for 30 min. Then the mixture was cooled to room temperature and additional quantity of AlCl3 (1.0 equiv) was added. The mixture was stirred again at 80 oC for another 30 min. After completion of the reaction, the mixture was poured into ice-cold water (15 mL), stirred for 10 min and then extracted with ethyl acetate (3.x.5 mL). The organic layers were collected, combined, washed with water (3.x.10 mL), dried over anhydrous Na2SO4 and concentrated under vacuum. The residue was purified by column chromatography to afford the expected products.
The synthetic route of 25710-18-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kumar, K. Shiva; Adepu, Raju; Kapavarapu, Ravikumar; Rambabu; Krishna, G. Rama; Reddy, C. Malla; Priya, K. Krishna; Parsa, Kishore V.L.; Pal, Manojit; Tetrahedron Letters; vol. 53; 9; (2012); p. 1134 – 1138;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem