Application of 1111638-10-8,Some common heterocyclic compound, 1111638-10-8, name is 3-Chloro-5H-pyrrolo[2,3-b]pyrazine, molecular formula is C6H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 3-chloro-5H-pyrrolo[2,3-]pyrazine (1.00 g, 6.51 mmol) in DMF (33 mL) was added N-bromosuccinimide (1.159 g, 6.51 mmol). The reaction mixture was stirred at room temperature for 18 h. At completion, the reaction was concentrated and the resulting residue was treated with water (30 mL). The resulting slurry was stirred for 30 min, then filtered and washed with water (20 mL). The precipitate was dried for 3 h under vacuum at 70 C to afford crude 7-bromo-3-chloro-5H-pyrrolo[2,3-]pyrazine as brown solid (1.136 g, 48% yield). LCMS: m/z 232 (M+H)+, Rt= 0.80 min.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloro-5H-pyrrolo[2,3-b]pyrazine, its application will become more common.
Reference:
Patent; NOVARTIS AG; BAGDANOFF, Jeffrey T.; CHEN, Zhuoliang; DORE, Michael; FORTANET, Jorge Garcia; KATO, Misunori; LAMARCHE, Matthew J.; SARVER, Patrick James; SHULTZ, Michael; SMITH, Troy Douglas; WILLIAMS, Sarah; (156 pag.)WO2016/203404; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem