Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 87597-21-5, name is Ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of Ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate
Intermediate 1-07 (1.00 g, 2.87 mmol) was dissolved in DCM (28 mE) and N-bromosuccinimide (0.61 g, 3.44 mmol) and trifluoroacetic acid (0.25 mE) were added. The reaction mixture was stirring at rt for 16 h and then heated at 60 C. for 2 h more. The reaction mixture was cooled, andwashed with watet The organic phase was dried (Na2SO4), filtered and the solvent removed in vacuum. The residue was purified by biotage with a gradient cyclohexane/EtOAc:from 100% to 50:50 The desired fractions were collected to obtained 1.15 g of a white solid as intermediate 1-09 (Y:94%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); Serrano Marugan, Manuel; Pastor Fernandez, Joaquin; Martinez Gonzalez, Sonia; Ortega Molina, Ana; Bischoff, James R.; Oyarzabal Santamarina, Julen; (220 pag.)US9993554; (2018); B2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem