Synthetic Route of 1379338-74-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Intermediate 32: 1 ,1-Dimethylethyl {4-r(7-chloropyridor3,4-blpyrazin-5- vDaminolbutvDcarbamate; To 5,7-dichloropyrido[3,4-b]pyrazine (650mg, 3.25mmol) was added 1 , 1- dimethylethyl (4-aminobutyl)carbamate (0.622ml, 3.25mmol) (Fluka) and diisopropylethylamine (0.851 ml, 4.87mmol). To the mixture was added N-methyl-2- pyrrolidone (NMP) (10ml). The microwave vial was sealed and heated to 130C for 30min. The reaction mixture was partitioned between water (70ml) and ethyl acetate (70ml) and then separated. The aqueous layer was extracted with ethyl acetate (2x50ml). The combined organics were passed through a phase separation cartridge and reduced in vacuo. The residue was dissolved in DCM and loaded onto a silica cartridge (50g) and purified via SP4 using a 15-75% EtOAc in cyclohexane gradient. The appropriate fractions were combined and concentrated to give the title compound as a yellow film (1.01g).LCMS (Method C): Rt = 1.11 min, MH+ = 352.0
The synthetic route of 5,7-Dichloropyrido[3,4-b]pyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; ATKINSON, Francis Louis; ATKINSON, Stephen John; BARKER, Michael David; DOUAULT, Clement; GARTON, Neil Stuart; LIDDLE, John; PATEL, Vipulkumar Kantibhai; PRESTON, Alexander G; SHIPLEY, Tracy Jane; WILSON, David Matthew; WATSON, Robert J; WO2012/123312; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem