Electric Literature of 1049026-49-4, A common heterocyclic compound, 1049026-49-4, name is 2-Bromo-5-(methylthio)pyrazine, molecular formula is C5H5BrN2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step B: 2-bromo-5-(methylsulfonyl)pyrazine: An aqueous solution of Oxone (4.0 g, 6.6 mmol,3.13 mL) was added dropwise to a methanol solution of 2-bromo-5-(methylsulfanyl)pyrazine(450 mg, 2.2 mmol, 19 mL) at ambient temperature. The reaction mixture was stirred for 3hours, filtered over a pad of CELITE and then organic layer was concentrated in vacuo. The crude residue was purified via MPLC (0-100% EtOAc/hexane gradient) to afford titlecompound.
The synthetic route of 1049026-49-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP; TANG, Haifeng; PIO, Barbara; JIANG, Jinlong; PASTERNAK, Alexander; DONG, Shuzhi; FERGUSON, Ronald Dale, II; GUO, Zack Zhiqiang; CHOBANIAN, Harry; FRIE, Jessica; GUO, Yan; WU, Zhicai; YU, Yang; WANG, Ming; WO2015/17305; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem