Adding a certain compound to certain chemical reactions, such as: 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 762240-92-6, Formula: C6H8ClF3N4
100 g of 3-tert-butoxycarbonylamino-4-(2,4,5-trif- luorophenyl)butyric acid of formula (II) was charged with 800 ml of toluene into a 2 litre 4 necked round bottom flask attached with dean stark apparatus followed by 70 ml of triethyl amine at room temperature. Then 100 g of 3-(trifluo- romethyl)-5,6,7,8-tetrahydro-[ 1 ,2,4]triazolo[4,3-a]pyrazine HC1 was charged and stirred for 5 minutes. 7.5 g of phenyl boronic acid was charged to the reaction mass. Afier 48 hours of stirring at reflux temperature, the reaction was complete. The reaction mass was cooled to room temperature and 1000 ml of water was added to it. The organic layer was separated and washed twice with 500 ml of iN HC1. The organic layer was separated and washed with 500 ml of water followed by 6% NaHCO3 and finally by 500 ml ofwater. The organic layer was then separated, treated with sodium sulfate and then with charcoal and filtered. The solvent was distilled out under vacuum. The solid obtained was stirred with 500 ml of diisopropyl ether for 2 hours, filtered, washed with diisopropyl ether and then dried under vacuum at 50 C. for 12-15 hours. 10078] HPLC was used to obtain the chromatographic purity and chiral purity.Weight: 140 g (140.0% w/w, 91.95%) Chromatographic purity: >98.0%Chiral purity (calculated as [desired enantiomer]/[desired enantiomer+undesired enantiomer]x 100): >99.5%
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Rao, Dharmaraj Ramachandra; Kankan, Rajendra Narayanrao; Ghagare, Maruti; Kadam, Swati Atul; US2015/197523; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem