Related Products of 5521-55-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5521-55-1 as follows.
A. Ethyl 5-methyl-2-pyrazinecarboxylate 5-methyl pyrazine-2-carboxylic acid (6.65 g, 48.14 mmol) was refluxed in 50 mL of EtOH containing a few drops of H2SO4 for 5h and then cooled and concentrated. The residue was redissolved in EtOAc and washed 1 x NaHCO3, 1 x brine and the organics dried (Na2SO4), filtered and concentrated to give the title compound (7.05 g, 42.42 mmol, 88% yield) as a pale yellow oil :’H NMR (CDCI3, 400 MHz) 8 9.16 (s, 1H), 8.55 (s, 1H), 4.47 (dd, J= 14.1, 7.1 Hz), 2.64 (s, 3H), 1.42 (t, J = 7. 2 Hz, 3H).
According to the analysis of related databases, 5521-55-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2003/76440; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem