Related Products of 25710-18-3, These common heterocyclic compound, 25710-18-3, name is 2,3-Dichloropyrido[2,3-b]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of 2,3-dichloropyrido[3,2-b]pyrazine (3) (4.76 g, 18.5 mmol) in dimethylsulfoxide (DMSO, 2 ml) solution was added phenylacetylene (2.3 ml, 21.3 mmol), triethylamine (18.0 ml, 129.6 mmol), palladium(II) acetate (290 mg, 1.3 mmol), copper(I) iodide (437 mg, 1.7 mmol) and triphenylphosphine (388 mg, 2.0 mmol) at 80 °C for 2 h. The resulting mixture was concentrated in vacuum to remove the solvent and then water was added. The mixture was extracted with ethyl acetate and the organic layer was washed with water and dried over MgSO4. After removal of solvent in vacuum, the residue was purified by SiO2 column chromatography (CH2Cl2/n-hexane = 3:2) to yield the desired compound 4, 2-chloro-3-(phenylethynyl)pyrido[3,2-b]pyrazine (83percent, 4.6 g). 1H NMR (500 MHz, CDCl3) delta 7.46 (m, 6H), 7.73 (m, 6H), 8.34 (d, J = 8.3 Hz, 2H), 9.19 (dd, J = 2.31, 1.8 Hz, 2H); MS (ESI) m/z 266 ([M+H]+).
The synthetic route of 25710-18-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Gong, Young-Dae; Dong, Mi-Sook; Lee, Sang-Bum; Kim, Nayeon; Bae, Mi-Seon; Kang, Nam-Sook; Bioorganic and Medicinal Chemistry; vol. 19; 18; (2011); p. 5639 – 5647;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem