These common heterocyclic compound, 312736-50-8, name is 3,5-Dichloropyrazine-2-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 3,5-Dichloropyrazine-2-carboxamide
A mixture of 3,5-dichloropyrazine-2-carboxamide (3b, 450 mg, 2.34 mmol), 3-(methanesulfonyl)aniline (441 mg, 2.58 mmol), DIPEA (408 muL, 2.34 mmol) and 1,4-dioxane (20 mL) was stirred 110 C for 60 h. After the mixture was cooled, water was added, and the resulting slurry was extracted with EtOAc. The organic layer was dried over anhydrous MgSO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (CHCl3/MeOH=100:0 to 50:1).The resulting product was washed with EtOAc to give 4b (425 mg,55%) as a pale yellow solid. 1H NMR (DMSO-d6): delta 3.24 (3H, s),7.55-7.77 (2H, m), 7.90-8.04 (1H, m), 8.06-8.36 (3H, m), 8.50 (1H, s),11.73 (1H, s); MS (FAB) m/z [M+H]+ 327.
The synthetic route of 3,5-Dichloropyrazine-2-carboxamide has been constantly updated, and we look forward to future research findings.
Reference:
Article; Iikubo, Kazuhiko; Kurosawa, Kazuo; Matsuya, Takahiro; Kondoh, Yutaka; Kamikawa, Akio; Moritomo, Ayako; Iwai, Yoshinori; Tomiyama, Hiroshi; Shimada, Itsuro; Bioorganic and Medicinal Chemistry; vol. 27; 8; (2019); p. 1683 – 1692;,
Pyrazine – Wikipedia,
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