Electric Literature of 14508-49-7,Some common heterocyclic compound, 14508-49-7, name is 2-Chloropyrazine, molecular formula is C4H3ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 1. Preparation of 4-{[4-(5-butylpyrazin-2-yl) piperazin-1- yl] sulfonyl}-N-hydroxytetrahydro-2H-pyran-4-carboxamide dihydrochloride. [793] Part A. Preparation of :; To a DMSO solution (350 mL) of chloropyrazine (21.3 g, 187 mmol) and 1-Boc- piperazine (31.6 g, 170 mmol) was added Cs2C03 (77g, 237 mmol). The slurry was stirred at 60C for 24 hr, and at 100C for an additional 24 hr. The cooled mixture was diluted with water (800 mL), and extracted with diethyl ether (3×500 mL). The combined organic extracts were washed with brine, dried over MgS04, and evaporated to a brown oil. The crude material was purified on a plug (200 g) of silica gel eluting with 10-40% ethyl acetate in hexane to produce 31.7 g (71%) of the desired compound in the form of a pale yellow solid. MS: 7t1/Z = 265.1 (M+H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloropyrazine, its application will become more common.
Reference:
Patent; PHARMACIA CORPORATION; WO2005/42521; (2005); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem