Electric Literature of 69214-34-2,Some common heterocyclic compound, 69214-34-2, name is 8-Bromoimidazo[1,2-a]pyrazine, molecular formula is C6H4BrN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 8.-hrornoirnidazo[ I ,2apyrazine (100 mg, 0.51 rnrnol) and selectfluor (214mg, 0.61 rnmol) in MeCN (5 mL) was heated to 70 C for 1 hour, After LCMS, it was indicatedthat starting material disappeared. The mixture was then concentrated, and the residue was purified by Prep-HPLC to give the title compound (40 mg) as a yellow solid. LRMS miz (M+H) 216.1, 218.1 found, 216.1, 218.1 required.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 8-Bromoimidazo[1,2-a]pyrazine, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; KUDUK, Scott D.; BESHORE, Doug C.; MENG, Na; LUO, Yunfu; (127 pag.)WO2016/101119; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem