Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5521-61-9, name is 6-Methylpyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H6N2O2
Example 14: 6-.Meth lA^(1^ yl)pyrazjne~2-carboxamideExample 14 was prepared from intermediate 2-A by amidation reaction with 6-meih lpyrazine- 2-carboxylic acid, as follows:To a solution of 2-A (80 nig, 0.35 nimol) and 6~nieih> pymzine-2-carboxylic acid (58 mg, 0.42 mmol) in DMF (5 ml.) was added DOHA (92 mg, 0.70 mmol) and HATU (338 mg, 0.70 mmol) under a. After stirring at room iemperature for an hour, the reaction was quenched with brine and extracted with ethyl acetate (3 x 20 ml..). The combined organic phase was washed with brine, dried over NajS(¾ and concentrated under reducced pressure. The residue was purified by Prep HPLC to yield 78 mg (64percent) of the title ompound, 6-raefh Iota-lambda’-((1 R,5S)-5-(r ridm-2- as an off-white solid. .H NMR (500 MHz, CDCI3); S 9.18 (s, 1 E), 8.60 (s, IH), 8.55 (4 J * 4.7 Hz, 1.H), 7.94 (s. 1 H), 7.62 (m, 1 H), 7.38 (d,J- 7.8 Hz, IH), 7.19 (m, 1 H), 2.60 (s, 3H), 2.53 {<1, J- 10.7 ¾ I H), 2.25 (m, IH), 2.18 - 1.70 (in, 10H); RSI-MS m/z: 347 (M+B)'*'.
The synthetic route of 5521-61-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; H. LUNDBECK A/S; LI, Guiying; DOLLER, Dario; WO2013/40535; (2013); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem