In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 77168-85-5 as follows. Quality Control of Methyl 5-chloro-6-methylpyrazine-2-carboxylate
[0145j A solution of methyl 5-chloro-6-methylpyrazine-2-carboxylate (1 g, 5.37 mmol) and potassium trimethyl silanolate (1.3 g, 10.7 mmol) in tetrahydrofuran (15 mL) was stirred at 70 °C under microwave irradiation for 20 minutes. Then the reaction mixture was acidified with iN hydrochloric acid to pH 3 and extracted with ethyl acetate (100 mL x 2). The combined organic extract was washed with brine (200 mL), dried over sodium sulfate and concentrated under vacuum to afford the title compound 5-chloro-6-methylpyrazine-2- carboxylic acid (0.800 g, crude) as a light yellow solid which was used for next step without further purification. Calculated M+H: 173.03; Found M+H: 173.33.
According to the analysis of related databases, 77168-85-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MNEMOSYNE PHARMACEUTICALS, INC.; ANDERSON, David R.; VOLKMANN, Robert A.; WO2015/48503; (2015); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem