Application of 160252-31-3, A common heterocyclic compound, 160252-31-3, name is 1-(5-Chloropyrazin-2-yl)ethanone, molecular formula is C6H5ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-(5-Chloropyrazin-2-yl)ethanone (2.8 g, 17.9 mmol) was dissolved in DMF (30 mL) and CF3CH2OH was added followed by the addition of NaH (1.07 g, 26.8 mmol, 60% dispersion) at 0 C. The mixture was stirred at 0 C. for 10 min. The reaction was quenched with sat. NH4Cl, extracted with EtOAc, dried over MgSO4, and evaporated. The crude material was purified by flash column (50 g SNAP, 8-20% EtOAc in hexane) to afford the title compound. LC/MS (m/z): 221 (M+H)+
The synthetic route of 160252-31-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck Sharp & Dohme Corp.; Berger, Richard; Blizzard, Timothy A.; Campbell, Brian T.; Chen, Helen Y.; Debenham, John S.; Dewnani, Sunita V.; Dubois, Byron; Gude, Candido; Guo, Zack Zhiqiang; Harper, Bart; Hu, Zhiyong; Lin, Songnian; Liu, Ping; Wang, Ming; Ujjainwalla, Feroze; Xu, Jiayi; Xu, Libo; Zhang, Rui; (64 pag.)US2018/9796; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem