These common heterocyclic compound, 165894-09-7, name is 7-Benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 165894-09-7
7-Benzyl-5,6,7,8-tetrahydroimidazo[1 ,5-a]pyrazine (4.89 g, 22.9 mmol) was dissolved in absolute ethanol (200 mL) and 10% palladium on carbon (4.88 g) was added to the solution. The mixture was placed under 1 bar of a hydrogen atmosphere and stirred vigorously overnight. Then it was filtered through celite rinsing with ethanol, concentrated and coevaporated with dichloromethane. The title compound was obtained as off-white oil (2.52 g).1H NMR (ODd3) 6 7.42 (s, 1H), 6.77 (s, 1H), 4.07 (s, 2H), 3.99 (t, J = 5.6 Hz, 2H),3.22 (t, J = 5.6 Hz, 2H), 1.76 (br s, 1 H). LC/MS m/z 124 [M+H].
The synthetic route of 7-Benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LABORATORIOS DEL DR. ESTEVE S.A.; DIAZ-FERNANDEZ, Jose Luis; ALMANSA-ROSALES, Carmen; NIECZYPOR, Piotr; WO2015/91795; (2015); A1;,
Pyrazine – Wikipedia,
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