Application of 1007128-70-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1007128-70-2, name is 5,8-Dibromopyrido[3,4-b]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
In a 100 mL round bottom flask, under nitrogen, 5,8-Dibromo-pyrido[3,4-b]pyrazine (500.0 mg; 1.731 mmol) was dissolved in anhydrous methanol (50.0 ml). A 0.5M solution of sodium methoxide (5.2 ml; 2.596 mmol) in methanol was added to the beige solution. The beige suspension was heated to 60 C and the tan solution was stirred at 60 C for 30 min. The tan solution was cooled to room temperature, quenched with water (10 mL) and concentrated under reduced pressure. The residue was suspended in water (50 mL). The beige suspension was stirred at room temperature for 30 min. The beige solid was filtered, washed with water and dried under vacuo to obtain 331 mg of an beige solid as the title compound (331.0 mg; 79.7 %). MS:240 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,8-Dibromopyrido[3,4-b]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK PATENT GMBH; SHERER, Brian; LAN, Ruoxi; BRUGGER, Nadia; CHEN, Xiaoling; TOURE, Momar; CLEARY, Esther; DESELM, Lizbeth Celeste; WANG, Yanping; (397 pag.)WO2020/25517; (2020); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem