Some common heterocyclic compound, 2881-85-8, name is 3-Phenyl-2-pyrazinecarboxylic acid, molecular formula is C11H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 2881-85-8
General procedure: To a round-bottom flask was added acid (8.0 mmol, 1.0 equiv.), methoxyamine hydrochloride (12 mmol, 1.5 equiv.), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI, 12 mmol, 1.5 equiv), the mixture was well stirred in dry CH2Cl2 (24 mL), then N,N-dimethylpyridin-4-amine (DMAP, 24 mmol, 3.0 equiv) was added, the reaction was allowed to stir for overnight. Then the reaction was quenched with water and extracted with EtOAc. The organic layer was combined and dried over anhydrous sodium sulfate. After filtration and concentration, the residue was applied to a flash column chromatography to give 1.58 g of d in 71% yield as white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2881-85-8, its application will become more common.
Reference:
Article; Hu, Chunfang; Zhang, Zhiguo; Gao, Wenjing; Zhang, Guisheng; Liu, Tongxin; Liu, Qingfeng; Tetrahedron; vol. 74; 6; (2018); p. 665 – 671;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem