74290-68-9, name is 6-Bromo-5-methylpyrazin-2-amine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 6-Bromo-5-methylpyrazin-2-amine
A mixture of compound 15a (100 g, 0.53 mol) and ClCH2CHO (500 g (400 mL), 3.20 mol, 50 wt % aqueous solution) in H2O (600 mL) was refluxed for 5 h. The reaction mixture was concentrated to remove ClCH2CHO then extracted with EtOAc (600 mL¡Á3). The combined organic layers were concentrated and recrystallized from EtOAc and petroleum ether. The mother liquor was purified by column chromatography eluted with petroleum ether/EtOAc (2:1?1:1) to give 5-bromo-6-methylimidazo[1,2-a]pyrazine 1 (50 g, 44%) as a yellow solid; mp 145-148 C; IR (KBr): 3100, 1495, 1324, 1295, 1145, 771 cm-1; 1H NMR (400 MHz, CDCl3): delta=8.99 (s, 1H), 7.87-7.84 (m, 2H), 7.69 (s, 3H); 13C NMR (100 MHz, CDCl3): delta=140.0 (2C), 139.0, 134.8, 115.0, 110.4, 22; HRMS-ESI: calcd for C7H7BrN3 (M+H)+: 211.9823 and 213.9803; found: 211.9817 and 213.9797.
The synthetic route of 74290-68-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Harris, Anthony R.; Nason, Deane M.; Collantes, Elizabeth M.; Xu, Wenjian; Chi, Yushi; Wang, Zhihan; Zhang, Bingzhi; Zhang, Qingjian; Gray, David L.; Davoren, Jennifer E.; Tetrahedron; vol. 67; 47; (2011); p. 9063 – 9066;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem