Some common heterocyclic compound, 213019-67-1, name is 3-(Trifluoromethyl)pyrazin-2-amine, molecular formula is C5H4F3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 3-(Trifluoromethyl)pyrazin-2-amine
N-lodosuccinimide (3.4g, 15mmol) was added to a stirred suspension of 2-amino-3- trifluoromethylpyrazine (1 .63g, 10mmol) and trifluoroacetic acid (340mg, 3mmol) in acetonitrile (20ml) at room temperature. After stirring at room temperature for another 18 hours, the mixture was filtered. The filtrate was diluted with ethyl acetate and washed with a saturated aqueous solution of sodium thiosulfate. The organic layer was dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate = 5:1 as eluent to give 2-amino-3-trifluoromethyl-5-iodopyrazine (1.27g, 44%) as a yellow solid. (0278) 1H NMR (300Mz, DMSO-d6): delta 8.48 (s, 1 H), 7.06 (br s, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 213019-67-1, its application will become more common.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WAILES, Jeffrey, Steven; CARTER, Neil, Brian; CLOUGH, John, Martin; WILLIAMS, John; (57 pag.)WO2019/57723; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem