Related Products of 1007128-70-2,Some common heterocyclic compound, 1007128-70-2, name is 5,8-Dibromopyrido[3,4-b]pyrazine, molecular formula is C7H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 50 mL round bottom flask, fitted with a condenser and under nitrogen, 5,8-Dibromo-pyrido[3,4-b]pyrazine (750.0 mg; 2.518 mmol), sodium iodide (1.1 g; 7.554 mmol) and chlorotrimethylsilane (319.6 m; 2.518 mmol) were added to anhydrous MeCN (5.0 ml). The brown suspension was heated to reflux and the tan suspension was stirred at reflux for 2h. The tan suspension was let cool to room temperature, poured into water (70 mL) and the brown suspension was stirred at room temperature for 30 min. The beige solid was filtered and the solid was dissolved in DCM and MeOH, adsorbed on a PuriFlash lOg celite column and purified by chromatography on a PuriFlash 40g 30u column (DCM for 20 column volumes). The major product eluted between 0.9 to 3.9 column volumes. The pure fractions were concentrated under reduced pressure and the brown solid was dried under vacuo to give 492 mg of a brown solid as the title compound (492.0 mg; 56.1 %). MS:336 [M+H]+.
The synthetic route of 1007128-70-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK PATENT GMBH; SHERER, Brian; LAN, Ruoxi; BRUGGER, Nadia; CHEN, Xiaoling; TOURE, Momar; CLEARY, Esther; DESELM, Lizbeth Celeste; WANG, Yanping; (397 pag.)WO2020/25517; (2020); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem