These common heterocyclic compound, 5521-61-9, name is 6-Methylpyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 6-Methylpyrazine-2-carboxylic acid
Step 5: 5-|(6-Meth l-p razine-2-carbonyl)-amino|-bicyclo|3.2.1joctane-l-carboxylic acid ethyl ester5-Amino-bicyclo[3.2.1 ]octane- l -carboxylic acid ethyl ester (0.5 g, 2.53 mmol) was dissolved in methylene chloride (10.0 mL, 156 mmol). 6-Methylpyrazine-2-carboxylic acid (0.35 g, 2.53 mmol), benzotriazol- 1 -yloxytris(dimethylamino)phosphonium hexafluorophosphate ( .12 g, 2.53 mmol) and triethylamine (0.71 mL. 5.07 mmol) in methylene chloride (10.0 mL, 156 mmol) were added. The mixture was stirred at rt for 2 hours. The mixture was concentrated under reduced pressure. The resulting residue was purified on the Co b FI sh J system (hexane/ethyl acetate: 100/0 to 30/70 in 8 min, then hexane/ethyl acetate: 30/70) to afford 0.60 g (75percent) of the desired product. ESI-MS m/z: 3 18 (M + H)+
The synthetic route of 6-Methylpyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; H. LUNDBECK A/S; LI, Guiying; ZHOU, Hao; WEISS, Jesse; DOLLER, Dario; FORD, James; WO2012/88365; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem