Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2847-30-5, name is 2-Methoxy-3-methylpyrazine, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H8N2O
2-Methoxy-3-methylpyrazine 1a (3.72 g, 30 mmol) was added slowly to a stirred mixture of HNO3 (5.5 ml, 100%) and H2SO4 (11 ml, 98%) at 30-35 C. The reaction mixture was heated at 45 C for 4 h. Afterwards, it was poured over ca. 50 g of crushed ice and extracted with EtOAc (3¡Á50 ml). Combining the organic layers, washing with brine, drying (MgSO4), and removal ofsolvent afforded a mixture of products.The residue was subjected to column chromatography [eluting with hexane-EtOAc, 50:1? 5:1, Rf(2a) > Rf(3a) > Rf(4a) > Rf(5a)] to give pure products.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Yudin, Igor L.; Palysaeva, Nadezhda V.; Averkiev, Boris B.; Sheremetev, Aleksei B.; Mendeleev Communications; vol. 25; 3; (2015); p. 193 – 195;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem