Related Products of 74290-68-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 74290-68-9, name is 6-Bromo-5-methylpyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
6-Bromo-5-methylpyrazin-2-amine (which may be prepared according to the method ofN. Sato, J. Heterocycl. Chem. 1980, 171, 143-147) (2.40 g, 12.8 mmol), 4-[3-methyl-4-(4,4,5,5- tetramethyl- 1,3 ,2-d ioxaborolan-2-yl)phenoxy]furo[3,2-c]pyridine (C2) (4.48 g, 12.8 m mol), and tetrakis(triphenylphosphine)palladium(0) (95%, 466 mg, 0.383 mmol) were combined in a pressure tube and dissolved in 1 ,4-dioxane (60 mL) and ethanol (20 mL). A solution of sodium carbonate (2.0 M in water, 19.1 mL, 38.2 mmol) was added, and argon was bubbled through thereaction mixture for 15 minutes. The tube was sealed, and then heated at 140 00 for 16 hours. The reaction mixture was combined with a second, identical, reaction mixture for workup. The combined reaction mixtures were filtered; solids remaining in the reaction vessels were slurried in water and filtered, and the filter cake was washed with ethanol. All of the organic filtrates were passed through a pad of Celite, and the Celite pad was washed with ethanol. These filtrates were concentrated in vacuo, and the resulting solid was slurried in water, filtered and washedwith water. The solid was then slurried in 1:1 heptane I diethyl ether, filtered and washed withdiethyl ether to afford the product as a light yellow solid. Yield: 6.774 g, 20.38 mmol, 80%. 1HNMR (500 MHz, DMSO-d6) oe 8.14 (d, J=2.2 Hz, 1H), 8.01 (d, J=5.7 Hz, 1H), 7.82 (s, 1H), 7.47(dd, J=5.8, 0.9 Hz, 1H), 7.21 (d, J=8.3 Hz, 1H), 7.15 (brd, J=2.4 Hz, 1H), 7.09 (brdd, J=8.2, 2.4Hz, 1H), 7.06 (dd, J=2.2, 0.7 Hz, 1H), 6.18 (br s, 2H), 2.12 (s, 3H), 2.07 (br s, 3H).
The synthetic route of 6-Bromo-5-methylpyrazin-2-amine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; COE, Jotham, Wadsworth; ALLEN, John, Arthur; DAVOREN, Jennifer, Elizabeth; DOUNAY, Amy, Beth; EFREMOV, Ivan, Viktorovich; GRAY, David, Lawrence, Firman; GUILMETTE, Edward, Raymond; HARRIS, Anthony, Richard; HELAL, Christopher, John; HENDERSON, Jaclyn, Louise; MENTE, Scot, Richard; NASON, Deane, Milford, II; O’NEIL, Steven, Victor; SUBRAMANYAM, Chakrapani; XU, Wenjian; WO2014/72881; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem