In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25513-92-2 as follows. Application In Synthesis of Ethyl 3-methylpyrazine-2-carboxylate
Example 1.3: Preparation of 3-bromomethyl-pyrazine-2-carboxylic acid ethyl esterA mixture of 3-methyl-pyrazine-2-carboxylic acid ethyl ester (Example 1.1) (0.5 g), N-bromosuccinimide (“NuBS”) (0.536 g) and 2,2′-azobis(2-methylpropionitrile) (“AIBNu”) (0.487 g) in carbon tetrachloride (2.5 ml) was heated to reflux. After 1 hour thin layer chromatography showed a mixture of starting material and the desired product. Further NuBS (0.536 g) and AIBNu (0.243 g) were added and the reaction mixture heated for a further 1 hour. The percentage of product increased and impurities began to form. The reaction mixture was cooled to ambient temperature and then to 0C. The cold mixture was filtered and the filtrate concentrated. The residue was purified by chromatography on silica gel(eluent: 0-10% v/v ethyl acetate in zso-hexane) to give 3-bromomethyl-pyrazine-2-carboxylic acid ethyl ester (640 mg) contaminated with 3-methyl-pyrazine-2-carboxylic acid ethyl ester (due to co-elution, -3:2). MH+ – 245, RT = 1.26 min (Method A).
According to the analysis of related databases, 25513-92-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SYNGENTA LIMITED; WILLETTS, Nigel, James; MULHOLLAND, Nicholas, Phillip; WORTHINGTON, Paul, Anthony; AVERY, Alaric, James; WO2010/130970; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem