Application of 476622-89-6,Some common heterocyclic compound, 476622-89-6, name is 5-Bromo-2-iodo-3-methoxypyrazine, molecular formula is C5H4BrIN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: In a Schlenk flask, a solution containing the haloheterocycle (1mmol), the boronic acid (1.3mmol), methanol (5mL) and a 2M aqueous sodium carbonate solution (3.35mmol) in benzene (25mL) was deoxygenated by bubbling a stream of argon through it. Pd(PPh3)4 (0.14mmol) was then added and the flask was evacuated and purged with argon. The reaction mixture was heated for the time indicated and the reaction was quenched with water and extracted with CH2Cl2 (3×). The combined organic extracts were dried over Na2SO4, filtered and the solvent was evaporated in vacuo. The residue was purified by column chromatography on silica gel as indicated.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-2-iodo-3-methoxypyrazine, its application will become more common.