In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 73627-18-6 as follows. Product Details of 73627-18-6
Example 1 (6-chloro-pyrazolo[1,5-a]pyrimidin-2-yl)-(1-methyl-3,4-dihydro-1H-pyrrolo[ 1,2-a]pyrazin-2-yl)-methanone A solution of 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (181 mg, 0.92 mmol, 1.0 equiv), 1-methyl-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine (150 mg, 1.10 mmol, 1.2 equiv), EDC (176 mg, 0.92 mmol, 1.0 equiv) and HOAt (125 mg, 0.92 mmol, 1.0 equiv) in DMF (5 mL) was heated at 50C for 4 h. The mixture was allowed to cool to room temperature and poured into water and extracted with ethyl acetate. The combined organic layers were washed three times with brine, dried over Na2SO4 and concentrated. The residue was subjected to flash column chromatography (40% ethyl acetate in heptane) to yield 265 mg (91 %) of the title compound in good to moderate yield. LC/MS: m/z = 317 (MH+)
According to the analysis of related databases, 73627-18-6, the application of this compound in the production field has become more and more popular.