Adding a certain compound to certain chemical reactions, such as: 33332-30-8, name is 2-Chloro-6-methoxypyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33332-30-8, Recommanded Product: 2-Chloro-6-methoxypyrazine
To a solution of 0.49 g (0.0034 mol) of 2-chloro-6-methoxy-pyrazine (Example P7) in 9 mi of dichloromethane there are added, under an argon gas atmosphere, first, within a period of 45 minutes and at 20C, 0.19 g (0.002 mol) of hydrogen peroxide-urea adduct and then, dropwise, 0.3 ml (0.0021 mol) of trifluoroacetic anhydride in dichloromethane. Then there are again added, within a period of 45 minutes and at 20C, 0. 19 g (0.002 mol) of hydrogen peroxide-urea adduct and 0.3 ml (0.0021 mol) of trifluoroacetic anhydride in dichloro- methane, and the reaction mixture is stirred further at 20C for 30 minutes. The reaction is stopped by adding water, and the aqueous phase obtained is extracted with chloroform. The combined organic phases are washed with 5 % sodium hydrogen carbonate solution and saturated sodium chloride solution and dried over sodium sulfate. The desired title compound, having a melting point of 121-123C, is obtained in a yield of 0.53 g (98 % of theory). The compound can be used directly for the next reaction step. ‘H NMR (300 MHz, CDC13) : 7.802 ppm (d (J=1.2 Hz), 1 H) ; 7.691 ppm (d (J=1.2 Hz), 1 H) ; 4.012 ppm (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-6-methoxypyrazine, other downstream synthetic routes, hurry up and to see.