Electric Literature of 2882-21-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2882-21-5 as follows.
To a solution of 2-methoxy-6-methylpyrazine (21.3 g, 171.6 mmol) mAcOH (150 mL)was added NaBO2 H202 3H20 (31.7 g, 205.9 mmol). The mixture was stirred at 80C for 16 hours. The mixture was cocentrated in vacuo and diluted with 2 M aq. NaOH (300 mL). The mixture was extracted with EtOAc (200 mL x 4). The organic layer was washed with brine (100 mL), dried over Na2SO4 and concentrated in vacuo to give 3-methoxy-5-methylpyrazine1-oxide (14.4 g, 60% yield).
According to the analysis of related databases, 2882-21-5, the application of this compound in the production field has become more and more popular.