Some common heterocyclic compound, 723286-67-7, name is Ethyl 1,2,4-Triazolo[4,3-a]pyrazine-3-carboxylate, molecular formula is C8H8N4O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 723286-67-7
A mixture of 170 mg of ethyl [1, 2,4] triazolo [4, 3-a] pyrazine-3-carboxylate from Example 8, Step B and 3 mL of tert-butylamine was heated in a sealed tube at reflux for 8 h. Concentration followed by flash chromatography (silica gel, eluting sequentially with 100% ethyl acetate and 10% methanol/dichloromethane) gave the title compound as a viscous oil. LC/MS 219.9 (M+1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 723286-67-7, its application will become more common.