Reference of 40155-47-3,Some common heterocyclic compound, 40155-47-3, name is 3-Methoxypyrazine-2-carboxylic acid, molecular formula is C6H6N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of amine salt E1.1 (0.868g, 3.39 mmol) and carboxylic acid 1a (0.475g, 3.08 mmol) in DCE (50 mL) at room temperature was sequentially added bromotripyrrolidinophosphonium hexafluorophosphate (1.80 g, 3.85 mmol), and DIEA (1.59g, 112.33 mmol). The reaction was then stirred at room temperature for 72 hours. Then CH2CI2 (100 mL) and water (100 mL) were added to the reaction, layers separated, and the organic phase washed with water (2 x 100 mL), dried over Na2S04, and concentrated in vacuoto afford a residue. The residue was purified by column chromatography using silica gel, eluting with 100% EtOAc, to afford the desired compound as an off white solid (0.690g, 69% yield). LC-MS: mass calc’d. for C17H15CI2N5O2 [M+H]+ 356.1 , found 356.0; tR= 0.688 min.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Methoxypyrazine-2-carboxylic acid, its application will become more common.