Electric Literature of 43029-20-5, These common heterocyclic compound, 43029-20-5, name is 3-Amino-6-methylpyrazin-2(1H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE H3 3-Amino-1,6-dimethylpyrazin-2-one (Compound 14.12) 8.87 g of dimethyl sulfate are added dropwise to a mixture of 8.13 g of 3-amino-6-methylpyrazin-2-one and 72 ml of 1N sodium hydroxide solution at room temperature. After the mixture has been stirred at 20-25 C. for 15 hours, the precipitate is filtered off, the filtrate is concentrated to one quarter of the volume and the concentrate is extracted with ethyl acetate. 1.7 g of 3-amino-1,6-dimethylpyrazin-2-one with a melting point of 217-219 C. are obtained by washing with saturated sodium chloride solution, drying with sodium sulfate and concentrating the organic phase.
The synthetic route of 43029-20-5 has been constantly updated, and we look forward to future research findings.