Electric Literature of 127406-08-0,Some common heterocyclic compound, 127406-08-0, name is 4-(Pyrazin-2-yl)benzaldehyde, molecular formula is C11H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The compound from step A (6.2 g, 33.5 mmole), (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (22.6 g, 52.7 mmole), tris[2-(2-methoxyethoxy)ethyl]amine (11.2 ml, 34.9 mmole), sat. aq. K2CO3 (150 mls), and CH2Cl2 (150 ml) were heated at reflux for 17 hours. The mixture was cooled and the aqueous layer was washed with CH2Cl2 (2×). The combined organic layers were washed with NaHCO3, brine, dried (MgSO4), and concentrated.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Pyrazin-2-yl)benzaldehyde, its application will become more common.