Electric Literature of 33332-25-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.
Description 22 1,1-Dimethylethyl 7-((5-[(methyloxy)carbonyl]-2-pyrazinyl}oxy)-1,2,4,5-tetrahydro-3H- 3-benzazepine-3-carboxylate (D22); Sodium hydride (800 mg of 60% dispersion; 20 mmol) was added to a solution of 1,1- dimethylethyl 7-hydroxy-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (5 g; 19 mmol; obtainable by the process described in Description 3 from WO 02/40471) in dry dimethylformamide (40 ml) and the reaction stirred at room temperature for 45 minutes. Methyl 5-chloro-2-pyrazinecarboxylate (3.9 g; 22.8 mmol) was added and the mixture stirred at room temperature for 18 hours. The mixture was poured into water and extracted with diethyl ether. The extracts were combined, dried (sodium sulphate) and evaporated. The residue was purified by silica column chromatography eluting with 2-1 hexane – ethyl acetate to afford a white powder (4.6 g; 61%) 8(CDC13) 1.49 (s, 9H), 2.92 (m, 4H), 3.58 (m, 4H), 4.01 (s, 3H), 6.94 (m, 2H), 7.18 (m, H), 8.48 (s, H), 8.84 (s, H).
The chemical industry reduces the impact on the environment during synthesis Methyl 5-chloropyrazine-2-carboxylate. I believe this compound will play a more active role in future production and life.