Related Products of 19847-12-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19847-12-2, name is Pyrazinecarbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
(1) preparing a format reagent,Add magnesium, anhydrous polarity to a nitrogen-protected pressure vesselSolvent tetrahydrofuran and elemental iodine, then add methyl chloride to the pressure vessel and stir.After the pressure vessel is heated to 60 C and stirring is continued for 2 hours, a format reagent is prepared;Metal magnesium is newly formed magnesium, and the molar ratio of magnesium metal to chloromethane acid is 1:1.1;The content of elemental iodine is 0.21% × metal magnesium weight; the reaction equation is as follows:(2)Addition reaction, adding 2-cyanopyrazine and tetrahydrofuran to the reactor and heating the reactor to50 C, then add catalysisThe cuprous chloride and the reagents of the above format are then refluxed and condensed.After the end, the remaining part of the reactor is an intermediate product, wherein the addition reaction time is 14h;The molar ratio of 2-cyanopyrazine to the format reagent S1 is1:1.05; the content of cuprous chloride is 2.1% metal magnesium weight;(3)Hydrolyzing, adding water to the remaining intermediate product of the above reactor,The pH of the solution in the reactor was adjusted to 1 with dilute sulfuric acid, and then stirred for 12 hours.Adjusting the pH of the solution in the reactor to neutral with a saturated aqueous solution of sodium carbonate;Finally extracted with toluene three times;(4)After the treatment, the toluene extract is desolvated, and the solid after desolvation is dissolved by heating with ethanol.Add activated carbon, continue heating and reflux for 10 min, and filter.The filtrate was cooled to 5 C to obtain a white solid P1; then the white solid P1 was recrystallized from ethanol.Produced a white solid P2,Drying gives 2-acetylpyrazine;The purity of 2-acetylpyrazine was 98.4%, and the yield of 2-acetylpyrazine was 69%.The reagent polar solvents, elemental iodine, 2-cyanopyrazine, tetrahydrofuran toluene and ethanol were all analytically pure.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazinecarbonitrile, other downstream synthetic routes, hurry up and to see.