Electric Literature of 6924-68-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6924-68-1 name is Ethyl pyrazine-2-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Dissolve NaOMe (1.5 eq) in toluene and heat 90C. Add a solution of 2-pyrazine methylester (1.0 eq) and methyl acetate (2.0 eq) in toluene dropwise and heat at 90C. After 20 hours, cone. in vacuo at RT. Slurry in excess methyl acetate and reflux 20 hours. Cool to RT. Add water. Extract with EtOAc, dry (Na2SO4), filter and cone. in vacuo to give the title compound: TLC Rf= 0.58 (1: 1 EtOAc/hexanes)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl pyrazine-2-carboxylate, and friends who are interested can also refer to it.