Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5900-13-0, name is 5-Bromo-3-methoxypyrazin-2-amine, A new synthetic method of this compound is introduced below., Quality Control of 5-Bromo-3-methoxypyrazin-2-amine
To compound i-176 (20 g, 98 mmol, 1.00 eq.),2-isopropenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(17.3 g, 103 mmol, 1.05 equivalent) and Na2CO3 (20.8 g, 196 mmol, 2.00 eq.) in 1,4-dioxane (160 mL)Add Pd(dppf)Cl2 to the solution in H2O (40 mL)(1.43 g, 1.96 mmol, 0.02 eq.).The resulting reaction mixture was degassed twice, each time refilled with N2,Then heat to 90 C for 15 hours. The reaction mixture was cooled to EtOAc (EtOAc)EtOAc. Water (200 mL) was added to the filtrate.The two layers were separated and aqueous was extracted with EtOAc (2 The combined organic layers were washed with brine (200 mL)Dry over anhydrous Na2SO4, filter and concentrate under reduced pressure.The residue was purified by silica gel column chromatography to give a solid compoundI-170 (16g).
The synthetic route of 5900-13-0 has been constantly updated, and we look forward to future research findings.