Some common heterocyclic compound, 4774-14-5, name is 2,6-Dichloropyrazine, molecular formula is C4H2Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 4774-14-5
To a solution of 2,6-dichloropyrazine (5.0 g) in methanol (30 mL) was added sodium methoxide (2 eq.) and the reaction was refluxed overnight. To this was added additional NaOMe (3 eq.) and the reaction mixture was refluxed for 8 h. The reaction mixture was cooled to room temperature and concentrated. The residue obtained was washed with water and was extracted with ethyl acetate. The organic layer was separated, dried over sodium sulfate, filtered and concentrated. The oil obtained was placed under high vacuum overnight and was used as such for the next step (Yield: 3 g, Rf: 1.007 min, Condition B, M+41 : 186).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4774-14-5, its application will become more common.