Related Products of 55557-52-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of (1 r,4r)-4-( 1 -(3-(2-fluoropropan-2-yl)- 1 ,2,4-oxadiazol-5-yl)piperidin-4- yloxy)cyclohexanol (154 mg, 0.470 mmol) and 3-chloropyrazine-2-carbonitrile (83.8 mg, 0.601 mmol) in 2 mL THF, 1 M potassium tert-butoxide in THF (0.6 mL, 0.600 mmol) was added slowly. After stirring at rt for 0.5 h, the dark brown solution was extracted with water and CH2C12. Organic phases were dried over MgSO4, filtered, and concentrated. Residue was purified by Biotage column chromatography (Si02, hexane/AcOEt gradient). Fractions containing product were concentrated and re-purified by HPLC (CH3CN/H20 gradient + 0.1% TFA). Fractions containing product were partly concentrated and residue was extracted with 1 M NaHCO3 and CH2C12. Organic phases were dried over MgSO4, filtered, and concentrated to afford the title compound (125 mg, 0.290 mmol, 6 1.7%) as a white solid. Exact mass calculated for C2,H27FN603: 430.21, found: LC/MS m/z = 431.2 (M+H); ?H NMR (400 MHz, CDC13) oe ppm 1.51-1.60 (m, 2H), 1.66-1.76 (m, 1OH), 1.86-1.93 (m, 2H), 1.99-2.06 (m, 2H), 2.10-2.17 (m, 2H), 3.47-3.53 (m, 2H), 3.56-3.62 (m, 1H), 3.66-3.72 (m, 1H), 3.82-3.89 (m, 2H), 5.20-5.27 (m, 1H), 8.23 (d, J = 2.5 Hz, 1H), 8.30 (d, J = 2.5 Hz, 1H).
The chemical industry reduces the impact on the environment during synthesis 3-Chloropyrazine-2-carbonitrile. I believe this compound will play a more active role in future production and life.