In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 762240-92-6 as follows. Computed Properties of C6H8ClF3N4
General procedure: A solution of 3-(trifluoromethyl)-5,6,7,8-tetrahydro [1,2,4]triazolo[4,3-a]pyrazine hydrochloride salt 9 (1.0 eq.) in dimethylformamide (DMF, 2e3 mL) was added potassium carbonate (2.5eq.) at 5 C and stirred for 15 min at room temperature. To this,various chloride derivatives (1.0 eq.) in DMF was added to reaction mixture at same temperature. The resultant reaction mixture was allowed to stir at room temperature for 24 h. The completion of the reaction was monitored on TLC (using 10% MeOH: DCM and ammonia as a modifier as mobile phase). The reaction mixture was poured into ice-cold water and extracted with ethyl acetate(2 x 15 mL). Organic layers were combined and the combined organic layer was dried over sodium sulfate and concentrated under reduced pressure to afford crude material and crystallized it from methanol to get 3-(trifluoromethyl)-5,6,7,8-tetrahydro [1,2,4]triazolo [4,3-a]pyrazine derivatives (12f-12j) in good practical yield.2.1.7.1. (4-fluorophenyl) (3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (12f). Solid, m. p.179-185 C; Anal. Calcd for C13H10F4N4O: C, 49.69; H, 3.21; F, 24.18;N, 17.83; O, 5.09%; found C, 49.82; H, 3.28; N, 17.92%; IR (KBr) (numax,cm-1): 3023 (=C-Hstr), 2964 (C-Hstr), 1642 (C=Ostr), 1574 (C=Cstr),1321 (C-Nstr), 1245 (C-Fstr); 1H NMR (400 MHz, DMSO) delta 7.89-7.78(m, 2H, -Ar), 7.17 (t, J = 7.8 Hz, 2H, -Ar), 4.53 (s, 1H, C6), 4.35 (s, 1H,C6), 4.30e4.20 (m, 2H, C10), 3.81 (t, J = 5.4 Hz, 1H, C9), 3.71 (t,J = 5.4 Hz, 1H, C9); ESI-MS (m/z): 315.2 [M+1].
According to the analysis of related databases, 762240-92-6, the application of this compound in the production field has become more and more popular.