Application of 290-37-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 290-37-9, name is Pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
General Procedure 1:; Diazine Oxidation;The appropriate diazine (1 equiv.) and mCPBA (1 equiv.) were dissolved in DCM (0.2 M). The reaction was allowed to stir for 16 hours. PPh3 (0.5 equiv.) was then added to reduce any unreacted peracid and the mixture was stirred for an additional 4 h. The volatiles were evaporated under reduce pressure and the residue was purified via silica gel column chromatography.; Pyrazine N-oxide (80) Synthesised according to general procedure 1. Purification via silica gel column chromatography using 100% EtOAc then a mixture of 20% MeOH/EtOAc gave a white solid (88%). 1H NMR (300 MHz, CDCl3, 293K, TMS): delta 8.50 (2H, d, J=3.9 Hz), 8.14 (2 H, d, J=4.8 Hz).13C NMR (75 MHz, CDCl3, 293K, TMS): 147.8, 134.0.HRMS calculated for C4H4N2O1 (M+) 96.0324; Found: 96.0295.Melting point C.: 103.2-104.5IR (vmax/cm-1): 3120, 3088, 1595, 861, 847, 838.Rf (20% MeOH/EtOAc): 0.3
The synthetic route of Pyrazine has been constantly updated, and we look forward to future research findings.