These common heterocyclic compound, 312736-49-5, name is 3,5-Dichloropyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 312736-49-5
To a solution of 55A (10 g, 51.82 mmol) and HATU (21.67 g, 57 mmol) in DMF (50 mL), DIEA (19.86 mL, 1 14 mmol) was added. After 30 minutes, Nu,Omicron-dimethylhydroxylamine hydrochloride (6.09 g, 62.18 mmol) was added to the solution. The mixture was stirred for overnight. Water (300 mL) was added and extracted with EtOAc three times (100 mL). The crude product purified by flash chromatography to afford the desired product. MS (m/z) 236 [M+H]+.
The synthetic route of 3,5-Dichloropyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.