Electric Literature of 98-97-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 98-97-5 name is Pyrazine-2-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Pyrazine-2-carb aldehyde A round bottom flask was charged with pyrazine carboxylic acid (17.7 g, 140 mMol), methanol (200 mL) and conc. sulphuric acid (2 mL) and the mixture was stirred at reflux for 4 hrs then left to stand overnight. The next day the mixture was refluxed for 2 more hours. The solvent was then evaporated in vacuo, the residue was diluted with dichloromethane and neutralised with 20% sodium bicarbonate solution. The dichloromethane phase was dried over MgS04 and evaporated to give the crude product as an off-white solid. Purification by column chromatography (silica gel, dichloromethane) gave pyrazinecarboxylic acid methyl ester 13.5 g as a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Pyrazine-2-carboxylic acid, and friends who are interested can also refer to it.