Some common heterocyclic compound, 89283-32-9, name is (3-Chloropyrazin-2-yl)methanol, molecular formula is C5H5ClN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 89283-32-9
2-Chloro-3-chloromethyl-pyrazine: (3-Chloropyrazin-2-yl)-methanol (8.00 g, 0.0553 mol) was dissolved in toluene (40 mL) and N,N-dimethylformamide (2.1 mL, 0.028 mol). The solution was treated dropwise with thionyl chloride (4.44 mL, 0.0609 mol) over 10 min, keeping the temperature at 40 C. during the addition. After 30 min the reaction was quenched with 20 mL water and then solid sodium carbonate (7.7 g, 0.073 mol) was added to give a neutral pH. The mixture was filtered and the toluene layer was separated. The aqueous layer was re-extracted with 25 mL toluene and the combined toluene extracts were washed with water (25 mL). The toluene solution was evaporated to remove water. The product can be used without further purification or if desired purified by distillation at 58 C. (1 Torr) to give the title compound a colorless liquid. 1H NMR (CDCl3, 400 MHz): delta 4.82 (s, 2H), 8.32-8.43 (m, 1H), 8.47-8.57 (m, 1H). m/z [MH+] 163/165/167 (100/60/10).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 89283-32-9, its application will become more common.