Application of 110223-15-9,Some common heterocyclic compound, 110223-15-9, name is 2-Amino-3-benzyloxypyrazine, molecular formula is C11H11N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3-(benzyloxy)pyridin-2-amine (100 mg, 0.50 mmol) and sodium hydride (60% in mineral oil, 22 mg, 0.55 mmol) was dissolved in tetrahydrofuran (0.25M) and then 1-adamantyl isocyanate (106 mg, 0.6 mmol) was added dropwise and heating at reflux for 20 hours. After the reaction was cooled to room temperature, water was added to terminate the reaction, and extracted with ethyl acetate, drying the extracted solution over sodium sulfate, it was filtered and concentrated under reduced pressure. By separation and purification of the residue by column chromatography (ethyl acetate / n-hexane = 1/2) to give the title compound 50 mg at a yield of 26.6%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Amino-3-benzyloxypyrazine, its application will become more common.