762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C6H8ClF3N4
2,4,5-Trifluorophenylacetic acid (2-1) (available from several commercial suppliers) (0.25 g, 1.32 mol), Meldrum’s acid (0.21 kg, 1.45 mol), and DMAP (12.9 g, 0.11 mol) were charged into a 5 L three-neck flask. Acetonitrile (750 mL) was added in one portion at room temperature. N,N-diisopropylethylamine (492 mL, 2.83 mol) was added in one portion at room temperature while maintaining the temperature below 40 C. Pivaloyl chloride (178 mL, 1.45 mol) was added dropwise over 1 to 2 h while maintaining the temperature below 50 C. The reaction was aged at 45-50 C for 2-3 h. Triazole hydrochliride 1-4 (0.30 kg, 1.32 mol) was added in one portion at 45-50 C. Trifluoroacetic acid (30.3 mL, 0.39 mol) was added dropwise, and the reaction solution aged at 50-55 C for 6 h. Without further work-up, the crude reaction mixture containing 2-3 can be used directly for conversion inrto DP-IV inhibitors. The isolated solution yield was 88-90%.
The synthetic route of 762240-92-6 has been constantly updated, and we look forward to future research findings.