In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4858-85-9 as follows. Product Details of 4858-85-9
STEP1 Preparation of 2-chloro-3-hydrazinylpyrazine To a solution of 2,3-dichloropyrazine (10.0 g, 67.1 mmol) in EtOH (224 mL) was added hydrazine hydrate (6.72 g, 134 mmol) at room temperature. The reaction mixture was refluxed for 3 hours. A precipitated solid was collected by filtration, washed with EtOH and dried under vacuum to afford 2-chloro-3-hydrazinylpyrazine (7.80 g, 80%) as an orange solid. 1H-NMR (DMSO-d6, 400 MHz): delta 8.30 (1H, brs), 8.07 (1H, d, J=2.4 Hz), 7.57 (1H, d, J=2.8 Hz), 4.34 (2H, brs).
According to the analysis of related databases, 4858-85-9, the application of this compound in the production field has become more and more popular.