In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33332-28-4 as follows. SDS of cas: 33332-28-4
To a solution of 2-amino-6-chloropyrazine (1 g, 7.72 mmol) in anhydrous acetonitrile (10 mL) was gradually added NBS (4.12 g, 23.16 mmol, 3 equiv.) at 0°C. The reaction mixture was slowly warmed up to r.t. and stirred overnight then diluted with water and extracted with Et20. Combined organic layers were washed with water and brine, then dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude material was purified byflash chromatography on silica eluting with Hexane/EtOAc (1:1)to give the title compound (1.55 g, 5.39 mmol, 70percent) as a pale yellow solid. ESI-MS: 287.90 [M+H]+.
According to the analysis of related databases, 33332-28-4, the application of this compound in the production field has become more and more popular.