13301-04-7, name is Methyl 3,6-dibromopyrazine-2-carboxylate, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 13301-04-7
A mixture of 3,6-dibromopyrazine-2-carboxylic acid methyl ester (5.00 g, 17 mm), THF (1 0 0 m 1), cooled to -7 8 C. A solution of Diisobutylaluminium hydride (34 ml, 34 mmol) was slowly added dropwise at -78 C for 2 h. The reaction was quenched at -78 C by addition of glacial acetic acid and the solvent was removed by distillation under reduced pressure. The residue was dissolved in 3 N hydrochloric acid, the dichloromethane was added and the water was extracted and washed with saturated NaC1 The solution was washed, dried over anhydrous Na2S04, and the solvent was removed by distillation under reduced pressure. The residue was purified on a silica gel column to afford the title compound as an off-white solid
The synthetic route of 13301-04-7 has been constantly updated, and we look forward to future research findings.