In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33332-28-4 as follows. Safety of 2-Amino-6-chloropyrazine
Step 1 To 2-amino-6-chloropyrazine (1eq) in DMSO and water is added at 0C NIS (1.1 eq) in 3 portions. The mixture is stirred in the dark for 72 h. The mixture is poured into water, extracted with EtOAe and-evaporated. The crude material is purified via flash column chromatography.
According to the analysis of related databases, 33332-28-4, the application of this compound in the production field has become more and more popular.